Improving Male Fertility with Androferti

How does each ingredient in Androferti support male fertility? In this article, we look at the role of each ingredient in turn.

Zinc

Zinc is an essential mineral found in large amounts in animal foods such as meat, fish and eggs. Because it plays a central role in spermatogenesis (the production of mature sperm) and in DNA and RNA synthesis, zinc is considered an important element for male fertility.

Evidence suggests that zinc deficiency may delay the development of the male sex organs, and it is associated with low testosterone levels, poor sperm quality and an increased risk of male infertility.

Zinc is involved in cell signalling, enzyme activity, the regulation of normal growth and sexual maturation, and the reduction of mitochondrial oxidative stress. In male fertility, zinc plays a role in many areas, including total and progressive sperm motility, the acrosome reaction, sperm concentration and chromatin integrity, as well as maintaining normal sperm morphology.

Zinc deficiency in the seminal plasma of infertile men has been widely reported. An estimated 33% of the world’s population is at risk of zinc deficiency, most often because of low dietary intake. Thanks to its bactericidal effect, zinc also helps protect prostatic fluid against a potentially infectious vaginal environment, and helps maintain the energy balance and overall stability of sperm until fertilisation.

The recommended dietary allowance (RDA) of zinc for adult men is 11 mg .

Selenium

Selenium is a trace mineral with antioxidant properties that can neutralise free radicals, helping to suppress testicular toxicity and modulate DNA repair. It is also a vital component of the enzyme GPx4, which is required for sperm formation and maturation.

Selenium also plays a role in cell growth and in protecting proteins and cell membranes. It is positively associated with specific semen parameters such as progressive and total motility, sperm concentration, count and normal morphology — and, in turn, with more live births and a higher likelihood of pregnancy.

Selenium deficiency may reduce sperm quality because of the oxidative stress it places on sperm. Studies have also shown that seminal plasma selenium concentrations are higher in fertile men. Diet is the main source of selenium, and the amount in some plant foods depends on how rich the soil is in selenium. Fish, garlic, onions and broccoli are among the foods rich in selenium.

The recommended dietary allowance (RDA) of selenium for adult men is 55 micrograms .

Folic Acid

Folic acid, also known as folate or vitamin B9, is a water-soluble compound involved in the synthesis of DNA, RNA and amino acids. It is essential for DNA metabolism and is recognised as an essential micronutrient for spermatogenesis (the process of sperm production).

By protecting DNA against oxidative damage, folate also has antioxidant properties. It is abundant in green leafy vegetables (spinach, broccoli, lettuce) and animal products (liver, milk, eggs).

The recommended dietary allowance (RDA) of folic acid for adult men is 400 micrograms .

Vitamin E

Vitamin E is a fat-soluble vitamin that plays a major role in fighting oxidative stress, particularly by protecting cell membranes against free radicals and preventing lipid peroxidation.

This vitamin has several effects on male fertility, including a role in testosterone biosynthesis and in modulating the activity of the enzyme telomerase. Vitamin E deficiency may also cause abnormalities in the male reproductive system and, by lowering its quality, lead to oxidative damage to sperm and reduced sperm function.

Vitamin E is not produced by the human body and must be obtained from the diet. It is found in foods such as nuts, vegetable oils, seafood, cheese and eggs.

The recommended dietary allowance (RDA) of vitamin E for adult men is 15 mg .

Vitamin C

Vitamin C, also known as ascorbic acid, is a water-soluble molecule with antioxidant properties. It is also present in semen, where it improves sperm quality by protecting sperm against oxidative stress.

Oxidative stress occurs when the level of reactive oxygen species (ROS) in the body becomes too high. It is seen in people whose antioxidant defences are weakened by illness, ageing, an unhealthy lifestyle or exposure to environmental pollutants. ROS are produced continuously in the body, but in healthy people their levels are kept under control.

Elevated ROS may cause inflammation and tissue damage and increase the risk of chronic disease. There is also evidence that oxidative stress and high ROS levels contribute to male infertility. A sufficient daily intake of antioxidants such as vitamin C helps counter some of these harmful effects and can improve semen quality.

One study in infertile men found that taking 1,000 mg of vitamin C twice a day for up to two months increased sperm motility by 92% and sperm count by more than 100%. Vitamin C also improves other sperm parameters and reduces DNA fragmentation.

The recommended dietary allowance (RDA) of vitamin C for adult men is 90 mg per day .

Vitamin B12

Cobalamin, or vitamin B12, is involved in many physiological processes in the body, including sperm production, and helps improve semen parameters such as sperm quality and count. Vitamin B12 concentrations are often lower in infertile men than in fertile men.

The recommended dietary allowance (RDA) of vitamin B12 for adult men is 2.4 micrograms per day .

Coenzyme Q10

Coenzyme Q10 (CoQ10), also known as ubiquinone, is a molecule with strong antioxidant properties that plays an important role in protecting cell membranes and is essential for energy production in cells. Numerous studies have shown improvements in sperm parameters — such as count, motility and morphology — after CoQ10 supplementation.

CoQ10 has no official RDA; the amount commonly used in male fertility studies is 200 mg per day .

L-Carnitine

Carnitines play an essential role in cellular energy production, in protecting cell membranes and in exerting anti-apoptotic effects. They are continuously secreted in the epididymis, where their concentration is up to 2,000 times higher than in the blood.

A positive relationship between carnitines and sperm quality has been widely reported, and a direct link between L-carnitine and sperm motility has been demonstrated in numerous clinical studies. About 75% of the body’s carnitine comes from the diet, and 25% is synthesised from lysine and methionine. Animal foods such as red meat, fish, poultry and dairy products are important sources of carnitine.

L-carnitine has no official RDA; the amount commonly used in male fertility studies is 1,000 to 2,000 mg per day .

Clinical Studies

In a study conducted in 2017 at Taleghani Hospital in Tehran by the School of Medicine of Shahid Beheshti University of Medical Sciences, the effects of Androferti on sperm parameters were measured in 180 patients with oligospermia. Participants took two Androferti sachets a day for three months.

The results showed that Androferti significantly increased sperm concentration (p=0.0004). A significant association between taking the product and improved sperm morphology was also reported (p=0.01).

Another study examined the effects of four male fertility supplements on sperm quality. The results showed that Androferti, alongside other similar supplements, protects the body against oxidative stress through its antioxidant effects and increases the likelihood of success in assisted reproduction procedures such as IVF.

How Should Androferti Sachets Be Taken?

Take Androferti sachets twice a day, ideally 12 hours apart. Pour the contents of a sachet into half a glass of water, juice or any other cold drink, stir until dissolved, and drink it straight away.

Do not dissolve Androferti in hot drinks, as heat can damage its ingredients. Building a daily routine of taking the product at set times (for example, 8 a.m. and 8 p.m.) will give you better results.

Why Should Androferti Be Taken Twice a Day?

L-carnitine is one of the main ingredients in Androferti. It improves sperm motility and supports energy metabolism. Because L-carnitine has a short half-life (three hours), its blood concentration returns to baseline 12 hours after a dose. To maintain a steadier supply, it is better to split the daily amount into two doses. This way, the body can more easily maintain a consistent level of this important nutrient, and the effects are more noticeable.

How Long Should Androferti Be Taken?

Sperm maturation usually takes 74 days, and a further 20 days or so are needed before the sperm are able to fertilise an egg. This period is known as the sperm production cycle.

To see the initial effects of Androferti, it should be taken for at least one sperm production cycle; for optimal results, however, it is recommended to continue for two consecutive cycles (6 months).

Advice and Precautions

• If you are taking any medication, consult your doctor or pharmacist before taking Androferti.
• Do not exceed the recommended dose without consulting your doctor or pharmacist.

This article is for information only and does not replace a doctor’s diagnosis or prescription. To investigate the cause of infertility and choose the right treatment, please consult a specialist.